Fig. 4: Meta-analytic coactivation profiles of cognitive control regions and associated behavioral domains.

a Meta-analytic connectivity modeling (MACM) results using the anterior insula (AI) as the seed region. b MACM results using the dorsomedial prefrontal cortex and dorsal anterior cingulate cortex (dmPFC/dACC) as the seed region. All seed coordinates were defined based on the peak activations from the conjunction analyses between the ALE maps for Arithmetic-Number and Reading, with a focus on higher-level contrasts. The left panels show coactivation patterns and associated behavioral domains based on coordinates from adult studies, while the right panels shows the results based on coordinates from child studies. Coactivation patterns and associated behavioral domains were identified using studies retrieved from the BrainMap database via Sleuth (details for coordinates in Tables S17–S18). Introspection-related experiments (e.g., thirst, sleep; n = 1–7) were excluded from all AI behavioral profile histograms, as introspection was not the primary focus of the study. Red, green, blue, and yellow colors in histograms indicate action, cognition, emotion, and perception domains, respectively. L left, R right.