Fig. 1: Protein specific early serological responses for IgG and IgM in children compared to adults.
From: SARS-CoV-2 antibody responses in children exhibit higher FcR engagement and avidity than in adults
Children (Spike (S) n = 126, Nucleocapsid (N) ORF8, and OC43-S n = 78) in red and adults (n = 40) in black (A–C, G) IgG and (DEFH) (children n = 22, adults n = 40) IgM responses to (A, D) S, (B, E) N, (C, F) ORF8 and OC43 S (G, H) at acute infection timepoints (day 0–14 post infection) compared to children without PCR confirmed SARS-CoV-2 infection (n = 12, red open circles) and pre-pandemic adult controls (n = 48, also used to define a responder cut off as mean +2 SD, shown by dotted lines). Percentage donors with responses above the cut off are shown in grey boxes under groups. Individual data points are shown, with lines and error bars showing mean and standard deviations. Lower bars are not shown if at 0 or below. Differences between groups assessed using two-sided Kruskal Wallis test with Dunn’s Multiple comparisons, differences between children and adult responder status assessed with Fisher’s Exact test. All differences with p < 0.05 shown. Source data are provided as a Source Data file.
