Fig. 3: Correlation between loop lengths and types of Zn coordination. | Nature Communications

Fig. 3: Correlation between loop lengths and types of Zn coordination.

From: Structural basis for the recognition and ubiquitylation of type-2 N-degron substrate by PRT1 plant N-recognin

Fig. 3

a Sequence alignment of structurally available ZZ domains. PDB IDs and types of Zn ion coordination are indicated on the left. Conserved zinc-coordinating cysteine and histidine residues are marked with red and green boxes, respectively. The key determinants of hydrophobic type-2 N-degron in the loops are circled and labeled in red. b, c Structure superposition of PRT1ZZ with other known ZZ domain structures. Superpositions with ZZ domains possessing HxxxH-type ZZ domains are shown in (b), and HxxH and HxH-type ZZ domains are presented in c. PDB IDs: 6e86 (ZZZ3; white), 2e5r (Dystrobrevin alpha; blue), 4xi6 (Mindbomb1; orange), 6ww3 (HERC2; green), 5yp7 (p62/SQSTM1; magenta), 2dip (SWIM; gray), 1tot (CBP; salmon), and 6ds6 (p300; yellow).

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