Fig. 5: Visualizing differential correlations among gene pairs for Extracellular Matrix Production & Cell Membrane Module (m13). | Nature Communications

Fig. 5: Visualizing differential correlations among gene pairs for Extracellular Matrix Production & Cell Membrane Module (m13).

From: Mepolizumab alters gene regulatory networks of nasal airway type-2 and epithelial inflammation in urban children with asthma

Fig. 5

a Tower plot for participants receiving mepolizumab comparing before treatment to on treatment. Each gene is represented by a plot point. Each line corresponds to significant differential correlation between the gene pairs (FDR < 0.05). Red lines represent a gain of correlation (GOC). Isolated plot points represent genes with no significant differential correlations. X-axis represents composition of differential correlations (complete LOC on left, complete GOC on right). Y-axis reflects the absolute median differential correlation z-score for each gene. Genes highlighted in green are associated with airway inflammation. b Highlighted genes of interest and brief description. See supplementary Table 5 for gene description references. See supplementary data 2 for DGCA results for all significant gene pairs shown in figure and coordinate information for each gene.

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