Fig. 6: Gene enrichment analysis for differentially correlated genes. | Nature Communications

Fig. 6: Gene enrichment analysis for differentially correlated genes.

From: Mepolizumab alters gene regulatory networks of nasal airway type-2 and epithelial inflammation in urban children with asthma

Fig. 6

Enrichment of top Gene Ontology Biological Processes (GOBP) pathways (ranked by enrichment difference p value) for participants receiving mepolizumab therapy comparing before treatment to on treatment: Partitioned by top/bottom quartile of median differential z-score (1 = most negative, 2 = most positive/least negative). Size of point reflects partition enrichment score. Dashed line = significant in full module (p < 0.05). P values were obtained from two-sided tests and adjustments were not made for multiple comparisons. GOBP pathway genes present in each partition labeled by partition color (blue = 1, red = 2). a Type 2 inflammation module (eos1). b Extracellular Matrix Production & Cell Membrane Module (m13). See supplementary data 3 for full enrichment results for eos1, m13 modules (tab 1,2 respectively).

Back to article page