Fig. 7: Inhibition of innate immunity enhances digestion but compromises animal survival.

a Western blot images showing the levels of p-PMK-1 in L1 animals fed on heat-killed E. coli + S. saprophyticus for 4 days. The relative intensity of p-PMK-1 versus tubulin is quantified and shown. b Representative images and quantification of GFP expression in wild-type and fdr-1(ok3369) mutants carrying the sysm-1p::gfp reporter, with L1-stage animals fed on heat-killed E. coli + S. saprophyticus for 24 h. Scale bar, 100 μm. Mean ± SD; ****p < 0.0001 via two-sided t-test. c Developmental progression of N2, fdr-1 (ok3369), nsy-1(ag3)and nsy-1(ag3); fdr-1 (ok3369) animals grown on heat-killed E. coli + S. saprophyticus at 20 °C for 4 days. Scale bar, 200 μm. Mean ± SD; ns denotes p > 0.05, ****p < 0.0001 via two-sided t-test. d Survival curves of animals grown on heat-killed E. coli + S. saprophyticus at 20 °C. See Supplementary Data 4 for summary statistics. The Log-rank (Mantel–Cox) test was used for statistical analysis of lifespan. ns denotes p > 0.05, ****p < 0.0001 via two-sided t-test. For all panels, n = number of animals which were scored. Representative data shown is one of three biological replicates. Source data are provided as a Source Data file. See also Supplementary Fig. 9 and Supplementary Data 4.