Fig. 5: Structural comparison of DNA-bound MTA1c and bacterial 6mA MTases.
From: Mechanism for the substrate recognition by a eukaryotic DNA N6-adenine methyltransferase complex
a Structure of MTA1cMTA9–hmDNA–SAM complex. b Structure of Caulobacter crescentus CcrM–DNA–sinefungin complex (PDB ID: 6PBD). c Structure of Escherichia coli EcoP15I Mod–DNA complex (PDB ID: 4ZCF). d–f The catalytic pockets in MTA1cMTA9 (d), CcrM (e) and EcoP15I Mod (f). The key residues involved in catalysis and the target deoxyadenosine, as well as ligand SAM and sinefungin, are shown in magenta sticks.
