Fig. 2: Association of genetic features with drug side effects in the Open Targets and OnSIDES dataset.

Forest plot of ORs with 95% CI calculated for each genetic feature with drug side effects, adjusted for 16 phecode categories using a logistic regression model. Side effects were removed where the drug is approved for an indication that shares the same phenotype term. The genetic features are grouped by color according to their genetic evidence category. For each feature the proportion of unique genes with genetic evidence and an observed side effect over the total number of unique genes with genetic evidence is shown is recorded in red on the y-axis and the proportion of unique phenotypes with genetic evidence and an observed side effect over the total number of unique phenotypes with genetic evidence is recorded in blue. Panel a displays results for Open Targets (n = 1,254,900 independent drug–gene–phenotype combinations), whereas panel b displays results for OnSIDES (n = 1,158,368 independent drug–gene–phenotype combinations). The statistical test was two-sided and ORs with 95% CIs are defined in the forest plot as circles and error bars. The red dashed line represents the null odds ratio (OR = 1). CI confidence interval, OR odds ratio.