Fig. 6: Association of the SE-GPS-DOE with drug side effects in the Open Target and OnSIDES datasets.
From: Development of a genetic priority score to predict drug side effects using human genetic evidence
Association between positive SE-GPS-DOE and drug side effects among inhibitor drugs in the Open Target (n = 853,065) and OnSIDES (n = 625,606) datasets, and between negative SE-GPS-DOE and drug side effects among activator drugs in the Open Target (n = 297,705) and OnSIDES (n = 385,215) datasets. In logistic regression models, non-zero SE-GPS-DOE values were binarized and compared to scores of 0, adjusting for 16 phecode categories. The statistical test was two-sided and ORs with 95% CIs are defined in the forest plot as circles and error bars. The red dashed line represents the null odds ratio (OR = 1). CI confidence interval, OR odds ratio, SE-GPS-DOE side-effect genetic priority score with direction of effect.
