Fig. 6: Activities on Aβ1-42 fibrillization. | Nature Communications

Fig. 6: Activities on Aβ1-42 fibrillization.

From: Synthetic chaperone based on Hsp90-Tau interaction inhibits Tau aggregation and rescues physiological Tau-Microtubule interaction

Fig. 6

A, B Effects of compounds β-Tau, β-Hsp90, S4, S7, S4short, S7short and Resveratrol on Aβ1-42 fibrillization assessed by ThT-fluorescence spectroscopy at 10/1 (green bars), 1/1 (yellow bars) and 0.1/1 (blue bars, only for β-Hsp90) ratios of compound/Aβ1-42. Parameters are expressed as mean ± SE, n = 2 (technical replicates). Compounds were dissolved in water. The concentration of Aβ1-42 was 10 µM. A The relative t1/2 (%) was calculated with respect to the t1/2 of Aβ1-42 control, see supporting information for the detailed calculations. NA = No Aggregation over 42 h, and (B) The relative F (%) was calculated at 42 h related to the fluorescence plateau of Aβ1-42 control. C Transmission electron micrographs, Aβ1-42 control and in the presence of β-Hsp90 (10/1 and 1/1 ratios) and β-Tau (10/1 ratio).

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