Fig. 1: Overview of the MetaLCL study. | Nature Communications

Fig. 1: Overview of the MetaLCL study.

From: Trans-eQTL mapping prioritises USP18 as a negative regulator of interferon response at a lupus risk locus

Fig. 1

A Overview of the study design and participating cohorts. B Significant trans-eQTLs detected in the meta-analysis. The upper scatter plot shows the number of trans-eQTL target genes detected at each trans-eQTL locus with p < 5 x 10−8. Six trans-eQTL loci with the most target genes have been labelled with the name of the closest cis gene. The lower scatter plot shows all significant loci for each tested gene at the more stringent p < 1 × 10−11 threshold. Cis associations are located on the diagonal while putative trans associations are located off diagonal. The points represent two-sided p-values from inverse-variance weighted meta-analysis. Source data are provided as a Source Data file.

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