Fig. 1: Pipeline for the identification and characterization of the depolymerase domains.
From: Unlocking data in Klebsiella lysogens to predict capsular type-specificity of phage depolymerases
A Pipeline for the identification of depolymerase domain sequences from prophage proteomes. B Venn diagram of the depolymerase domain identified through the 3 methods employed. They involved the deep learning based method Deposcope, a method based on HMM profiles of proteins with depolymerase polysaccharides degrading activity using HHMscan and BLASTp to scan the proteins against a collection of characterized depolymerases from the literature. C Proportions of the depolymerase folds identified. D Bar plot of the number of prophages carrying at latest one depolymerase on the y-axis across each KL types represented on the x-axis. The KL types represented by less than 5 prophages were assigned to the “Other” category.
