Fig. 3: Ranking for potentially pathogenic or oncogenic variants (PPV/POVs) and associated candidate genes for African-inclusive prostate cancer (PCa) germline testing (GT). | Nature Communications

Fig. 3: Ranking for potentially pathogenic or oncogenic variants (PPV/POVs) and associated candidate genes for African-inclusive prostate cancer (PCa) germline testing (GT).

From: Pathogenic variants reveal candidate genes for prostate cancer germline testing for men of African ancestry

Fig. 3

A Ranking system overview based on variant, clinical and tumour features. B Ranking for 24 rare PPV/POVs identified in known PCa GT genes, including previously reported (known) and not reported (unknown) variants. C The 11 known PCa GT genes ranked by weight (total ranked score), prevalence and total number of variants. D Ranking for 142 reported (known) and not reported (unknown) rare PPV/POVs impacting 66 candidate genes not included in PCa GT panels. E Ranking by weight (ranked score) for all 78 known and unknown PCa GT gene candidates, with population-specific low-frequency (PSLF) candidates assessed independently and represented as gene duplicates (stars), while providing an additional gene candidate CREBBP.

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