Fig. 2: Substrate scope of reductive alkenylation of imines.
From: Dinickel-catalyzed enantioselective reductive addition of imines with vinyl halides
a Scope of different sulfonyl protecting groups. b Scope of aryl imines. c Scope of aliphatic imines. d Scope of vinyl chlorides. aReaction condition as shown in Table 1. bZnBr2 (20 mol%) was added. cImine 1 (1.5 equiv), vinyl chloride 2 (0.2 mmol) was reacted in THF (0.2 M) at 40 °C for 48 h. d40 °C, 48 h. eZnBr2 (1.0 equiv) was added, L3 as ligand, in THF (0.1 M) at 25 °C for 24 h. f40 °C for 24 h. TBDPS t-butyl-diphenylsilyl.
