Table 1 Comparison of IC50 values for isoxazole 1 and previously reported ACS inhibitors

From: Discovery and mechanism of a highly selective, antifungal acetyl-CoA synthetase inhibitor

IC50 (µM)

CnAcs1

CaAcs2

HsACSS2

PfAcAS

Isoxazole 1

8.6

>100

>100

ND

MMV084976

2.8

99

18a

0.073a

MMV019721

>100

ND

>100a

0.370a

MTB-9655

>100

ND

0.15 × 10−3b

ND

VY-3-249

>50

ND

1.2c

ND

  1. aData from ref. 17.
  2. bData from (Clinicaltrials.gov/study/NCT04990739).
  3. cData from ref. 36.
Back to article page