Fig. 5: Model of photorespiration acting as an interface between the environment and DNA methylation. | Nature Plants

Fig. 5: Model of photorespiration acting as an interface between the environment and DNA methylation.

From: Photorespiration is linked to DNA methylation by formate as a one-carbon source

Fig. 5

Formate produced during photorespiration enters C1 metabolism through THFS and MTHFD1, supplying C1 units for thymidylate synthesis, recycling of Hcy to methionine (Met) and SAM-dependent DNA methylation in leaves. Photorespiratory C1 flux (yellow) is modulated by environmental variables. Negative feedback from THFS/MTHFD1 controls serine-derived C1 flux through SHMT4 (blue), stabilizing C1 metabolism under fluctuating conditions. When fluctuations in photorespiratory C1 flux are not compensated by SHMT4, local SAM limitation and SAH build-up drive DNA methylation changes.

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