Fig. 3: The geroprotective role of PCC1 on HIS cells. | npj Aging

Fig. 3: The geroprotective role of PCC1 on HIS cells.

From: Single-cell profiling unveils a geroprotective role of Procyanidin C1 in hematopoietic immune system via senolytic and senomorphic effects

Fig. 3

A Venn diagram showing the interaction of upregulated aging-DEGs and downregulated PCC1-DEGs (top) and that of downregulated aging-DEGs and upregulated PCC1-DEGs (bottom). The black arrows indicate down- or upregulated rescue-DEGs. B Rose diagram showing the number of up/downregulated aging-, PCC1- and rescue-DEGs across various immune cell types. Bar plot showing the functional analysis of downregulated (C) and upregulated (D) rescue-DEGs. E Bar plot showing the relative mRNA level of senescence markers and SASP factors in HIS cells across the three groups. F Bar plot showing the ratio of downregulated rescue-DEGs relative to upregulated aging-DEGs (left) and the ratio of upregulated rescue-DEGs relative to downregulated aging-DEGs (right) across immune cell types. Volcano plot showing the rescue-DEGs in GRAN (G) and MC (H). Significance was calculated using two-way ANOVA test (E); ns, not significant, *P < 0.01, **P < 0.01, ***P < 0.001, ****P < 0.0001.

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