Fig. 7: The senolytic and senomorphic effects of PCC1. | npj Aging

Fig. 7: The senolytic and senomorphic effects of PCC1.

From: Single-cell profiling unveils a geroprotective role of Procyanidin C1 in hematopoietic immune system via senolytic and senomorphic effects

Fig. 7

A Dot plot showing the functional analysis of upregulated PCC1-DEGs in iSnC. Violin plot showing the inflammatory response score (B), oxidative stress response score (C), glycolysis and gluconeogenesis score (D), and response to lipid score (E) across the indicated groups. F Bar plot showing the CCK-8 assay on control and SnCs of RAW 264.7 cell line upon treatment of different concentrations of PCC1 (n = 5/group). G The FCM histograms (left) and column charts (right) showing the Annexin V/PI apoptotic assay on control and SnCs of RAW 264.7 cell line upon PCC1 treatment (n = 5/group). H The FCM histograms (up) and column charts (down) showing the MFI of β-Gal in RAW 264.7 cell line among the three groups (n = 5/group). The FCM histograms (left) and column charts (right) showing the levels of TNF-α (I) and IL-6 (J) in RAW 264.7 cell line among the three groups (n = 5/group). Significance was calculated using one-way ANOVA test (B–J); ns, not significant, *P < 0.01, **P < 0.01, ***P < 0.001, ****P < 0.0001.

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