Fig. 2: Associations between modifiable traits and total GMV.

The x axis shows the category domains, and the y axis represents regression coefficient. The dashed horizontal line marks the minimum absolute coefficient for factors that are statistically significant after multiple comparisons (Bonferroni correction, P < 2.75 × 10−4). A set of top risk traits was annotated. Models were adjusted for age at baseline, sex, ethnicity, assessment site, imaging center, TIV, and the time interval between baseline assessment and imaging visit.