Fig. 3: Heat map regarding the association between modifiable traits and regional GMVs.

Models were adjusted for age at baseline, sex, ethnicity, assessment site, imaging center, TIV, and the time interval between baseline assessment and imaging visit. The color of cells indicates the regression coefficient (β) between each modifiable trait and regional GMV (n = 35,195). P values were corrected using Bonferroni correction for multiple tests (* P < 2.75×10−4; ** P < 1.51×10−6; *** P < 8.29×10−9).