Fig. 4: Modifiable traits joint associations with GMVs and risk of brain disorders. | npj Aging

Fig. 4: Modifiable traits joint associations with GMVs and risk of brain disorders.

From: Modifiable traits and genetic associations with grey matter volume in mid-to-late adulthood: a population-based study in the UK biobank

Fig. 4

a The joint explanation of variance with all 182 traits in regional GMV. The detailed results are available in Supplementary Table 2. b The joint explanation of variance in total and regional GMV by different domain modifiable traits. R2 was calculated using PLS after adjusting for age at baseline, sex, ethnicity, assessment site, imaging center, TIV, and the time interval between baseline assessment and imaging visit. The detailed results are available in Supplementary Table 2. c Associations between the composite score of modifiable traits with brain disorders. The unfavorable profile was set as reference in each brain disorder. Dots represent HR horizontal lines indicate corresponding 95% CIs. The detailed results are available in Supplementary Table 4.

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