Table 2 The additive value of PhenoAge acceleration in predicting incident atrial fibrillation

From: Utility of biological aging acceleration in capturing transitions of atrial fibrillation and dementia: a population-based study

Reference model

New model

Continuous NRI (95% CI)

IDI (95% CI)

Chronological age

Chronological age + PhenoAge acceleration + Sex

0.3392 (0.3273–0.3511)

0.0140 (0.0134–0.0145)

Chronological age

CHARGE-AF score + PhenoAge acceleration

0.4779 (0.4658–0.4899)

0.0303 (0.0294–0.0312)

CHARGE-AF score

CHARGE-AF score + PhenoAge acceleration

0.0370 (0.0247–0.0492)

0.0029 (0.0026–0.0031)

  1. NRI net reclassification improvement, IDI integrated discrimination improvement, NA not applicable, CHARGE-AF Cohorts for Heart and Aging Research in Genomic Epidemiology atrial fibrillation.
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