Table 1 The efficiency of lysis by individual phage and phage cocktail against 50 strains of clinical Klebsiella pneumoniae
Strain ID | Sequence Type | Capsule Locus | Plaque-forming unit (PFU/mL) | |||
---|---|---|---|---|---|---|
ΦK2044 | ΦKR1 | ΦKR8 | Cocktail | |||
NTUH-K2044 | ST23 | KL1 | 3.2 × 1010 | 8.8 × 109 | 9.6 × 109 | 4.1 × 1010 |
FK1971 | ST23 | KL1 | 1.6 × 1010 | 9.4 × 109 | 8.7 × 109 | 2.8 × 1010 |
FK2652 | ST23 | KL1 | 2.5 × 1010 | 1.1 × 1010 | 1.4 × 1010 | 2.3 × 1010 |
FK3038 | ST23 | KL1 | 3.0 × 1010 | 1.0 × 1010 | 2.9 × 1010 | 3.3 × 1010 |
FK3907 | ST23 | KL1 | 2.8 × 1010 | 5.9 × 109 | 6.9 × 109 | 3.0 × 1010 |
FK4737 | ST367 | KL1 | 3.5 × 1010 | 3.0 × 1010 | 1.3 × 1010 | 3.6 × 1010 |
FK3680 | ST23 | KL1 | 2.1 × 1010 | 8.9 × 109 | 4.9 × 109 | 3.9 × 1010 |
FK3044 | ST65 | KL2 | – | – | – | – |
FK5537 | ST25 | KL2 | – | 2.6 × 107 | 1.8 × 1010 | 2.2 × 1010 |
FK6048 | ST65 | KL2 | – | – | 2.5 × 1010 | 3.4 × 1010 |
FK4176 | ST86 | KL2 | – | – | 5.3 × 108 | 9.9 × 108 |
FK4276 | ST86 | KL2 | – | 9.7 × 107 | 1.9 × 1010 | 3.0 × 1010 |
FK6923 | ST1333 | KL5 | – | 1.9 × 107 | 6.7 × 108 | 9.2 × 108 |
FK3068 | ST320 | KL9 | – | 9.8 × 109 | 1.7 × 1010 | 3.5 × 1010 |
FK4006 | ST462 | KL9 | – | – | – | – |
FK3150 | ST3869-2LV | KL10 | – | 2.9 × 1010 | 1.8 × 1010 | 4.3 × 1010 |
FK5223 | ST15 | KL19 | – | 8.8 × 109 | 1.2 × 1010 | 2.6 × 1010 |
FK1819 | ST11 | KL47 | – | 7.2 × 108 | 1.7 × 1010 | 3.1 × 1010 |
FK2262 | ST11 | KL47 | – | 9.0 × 107 | 2.2 × 108 | 5.7 × 108 |
FK2357 | ST11 | KL47 | – | 9.4 × 106 | 5.7 × 108 | 9.3 × 108 |
FK2686 | ST11 | KL47 | – | 1.7 × 108 | 6.3 × 108 | 7.6 × 108 |
FK2784 | ST11 | KL47 | – | – | – | – |
FK4724 | ST11 | KL47 | – | 3 × 1010 | 2.5 × 1010 | 3.3 × 1010 |
FK6696 | ST11 | KL47 | – | 9.7 × 107 | 2.8 × 108 | 6.2 × 108 |
FK5119 | ST363 | KL53 | – | 2.6 × 1010 | 2.2 × 1010 | 2.1 × 1010 |
FK1916 | ST29 | KL54 | – | 2.9 × 1010 | 2.7 × 1010 | 2.9 × 1010 |
FK3347 | ST29 | KL54 | – | 2.8 × 1010 | 2.7 × 1010 | 3.6 × 1010 |
FK3521 | ST29 | KL54 | – | – | – | – |
FK3616 | ST29 | KL54 | – | 1.6 × 1010 | 2.1 × 1010 | 2.3 × 1010 |
FK7757 | ST412 | KL57 | – | – | – | – |
FK8123 | ST412 | KL57 | – | – | – | – |
FK1541 | ST111 | KL63 | – | – | – | – |
FK2877 | ST11 | KL64 | – | – | – | – |
FK3092 | ST11 | KL64 | – | 1.1 × 1010 | 0.93 × 1010 | 1.2 × 1010 |
FK3642 | ST11 | KL64 | – | – | – | – |
FK4603 | ST11 | KL64 | – | 2.2 × 109 | 1.4 × 109 | 1.5× 109 |
FK5164 | ST11 | KL64 | – | – | – | – |
FK5222 | ST11 | KL64 | – | 5.8 × 107 | 2.2 × 107 | 4.5 × 107 |
FK6716 | ST11 | KL64 | – | – | – | – |
FK6777 | ST11 | KL64 | – | 4.0 × 108 | 3.3 × 108 | 3.5 × 108 |
FK6916 | ST11 | KL64 | – | – | – | – |
FK7009 | ST11 | KL64 | – | – | – | – |
FK7014 | ST11 | KL64 | – | 9.7 × 109 | 1.9 × 109 | 2.3 × 1010 |
FK7040 | ST11 | KL64 | – | – | – | – |
FK7072 | ST11 | KL64 | – | 1.3 × 1010 | 1.8 × 108 | 1.6 × 1010 |
FK7096 | ST11 | KL64 | – | 8.7 × 108 | 9.1 × 108 | 7.1 × 108 |
FK7156 | ST11 | KL64 | – | – | – | – |
FK7788 | ST11 | KL64 | – | – | – | – |
FK7792 | ST11 | KL64 | – | – | – | – |
FK6449 | ST11 | KL74 | – | – | – | – |