Fig. 6: Mechanism of Bacillus bacteria affecting the host RNAi pathway.
From: Bacillus secretes nucleases to degrade dsRNA, thereby reducing host’s susceptibility to RNAi

After dsRNA enters the insect gut, nuclease secreted by commensal bacteria partially degrades the dsRNA, preventing its absorption by the gut epithelial cells and thereby impairing its ability to execute RNAi function.