Fig. 9: Schematic illustration of the mechanism by which P. succinatutens-derived propionate alleviates gut inflammation and reduces fat accumulation. | npj Biofilms and Microbiomes

Fig. 9: Schematic illustration of the mechanism by which P. succinatutens-derived propionate alleviates gut inflammation and reduces fat accumulation.

From: Gut-resident Phascolarctobacterium succinatutens decreases fat accumulation via MYC-driven epigenetic regulation of arginine biosynthesis

Fig. 9

By measuring backfat thickness (BF) in 129 Yorkshire pigs and integrating 16S rRNA gene sequencing, metagenomic sequencing, and serum untargeted metabolomics, we found that P. succinatutens, fecal propionate, and serum arginine levels were significantly elevated in LBF pigs. Mechanistically, propionate attenuates gut inflammation by inhibiting the TLR4/MyD88/NF-κB signaling pathway, promotes de novo arginine synthesis by reducing chromatin accessibility at the MYC locus, and ultimately reduces fat deposition via the PI3K/Akt/FOXO3a signaling axis.

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