Fig. 2: The autochthonous gut microbiota affects the enhancement of SIM01-contained species. | npj Biofilms and Microbiomes

Fig. 2: The autochthonous gut microbiota affects the enhancement of SIM01-contained species.

From: The resident gut microbiome modulates the effect of synbiotics on the immunogenicity after SARS-COV-2 vaccination in elderly and diabetes patients

Fig. 2

A, B The changes in the sum relative abundance of three Bifidobacterium (A) or B. adolescentis (B) between baseline and 3-month postvaccination (p.v.) after subgrouping based on the increase or non-increase of SIM01-contained species within the SIM01 arm. Non-Increase, N = 34 each time point. Increase, N = 110 at each time point. C The depleted species at baseline in the gut of subjects who were characterized by an increase in SIM01-contained species after 3 months of treatment. Maaslin2 was used for identification after adjusting the gender, age, and T2D status. p < 0.05, FDR <0.25. D Correlation between fold change of SIM01 species and the overlap number of the KO-encoded in SIM01 strains in the baseline samples. Coefficients and p values of the correlations were given by Spearman’s correlation tests. E The heatmap showed the presence and absence of baseline KOs that were associated with the enhancement of SIM01-related species after 3 months of SIM01 intervention. Each row represents the baseline sample of each subject.

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