Fig. 2: Ecological organization and reproducibility of colorectal cancer–associated gut microbiomes.
From: Cross-cohort resistome and virulome gradients structure the colorectal cancer microbiome
a Alpha-diversity metrics across clinical stages showing comparable within-sample diversity (i, Richness; ii, Shannon; iii, Simpson). b Non-metric multidimensional scaling (NMDS, Euclidean distance) reveals modest but significant compositional restructuring among Healthy, Adenoma and Cancer groups. c Reproducibility of CRC-associated taxa: i, core species enriched across cohorts; ii, Venn comparison of taxa shared with reference CRC datasets16,29; iii, clustered heatmap showing consistent stage-associated abundance profiles (Z-score). d Co-occurrence networks of reproducible taxa highlighting core commensals (R. intestinalis, A. hallii, B. wexlerae) as major ecological hubs forming stable, functionally cohesive modules across CRC progression.
