Fig. 3: Indicator and predictive species defining stage-specific microbiome signatures.
From: Cross-cohort resistome and virulome gradients structure the colorectal cancer microbiome
a Indicator-species analysis (IndVal.g) identifies taxa significantly associated with Healthy, Adenoma and Cancer stages (Benjamini-Hochberg-adjusted p ≤ 0.05). b Performance of supervised classifiers discriminating CRC stages from species-level abundance profiles. Models (Random Forest i, and Gradient Boosting ii) were trained as multi-class classifiers. ROC curves were generated using the standard one-vs-rest (OvR) extension of ROC analysis, where a separate ROC curve is computed for each class based on its predicted probability scores. iii Consensus feature ranking across models highlights robust discriminative taxa, including A. hallii, Blautia hansenii, Butyrivibrio fibrisolvens, and R. intestinalis.
