Table 2 Multivariable model for pCR
From: Clinico-pathological factors predicting pathological response in early triple-negative breast cancer
Characteristic | N | OR [95% CI] | p-value |
|---|---|---|---|
Germline mutation (BRCA1/2, PALB2, RAD51C) | <0.001 | ||
No | 175 | Reference | |
Yes | 32 | 9.50 [2.37–67.7] | |
Stage | 0.092 | ||
II | 149 | Reference | |
III | 58 | 0.53 [0.25–1.11] | |
Grade | 0.80 | ||
II | 27 | Reference | |
III | 180 | 1.18 [0.40–3.30] | |
DCIS on pre-treatment biopsy | 0.024 | ||
Yes | 34 | Reference | |
No | 157 | 2.56 [1.08–6.25] | |
Missing | 16 | 3.33 [1.03–11.11] | |
Ki-67 | 0.003 | ||
<30% | 22 | Reference | |
≥30% | 185 | 5.19 [1.73–17.3] | |
Centralized TILs | 0.010 | ||
<30% | 106 | Reference | |
≥30% | 75 | 3.08 [1.42–7.04] | |
Missing | 26 | 2.56 [0.89–8.47] | |
