Table 2 Invasive disease-free survival events in this series
Patient ID | iDFS event | No. foci at initial DCIS-MI diagnosis | Local treatment(s) | SLNB | ER/PR at initial DCIS-MI diagnosis | Adjuvant antiestrogen therapy | Adjuvant CT/H2TT | Timea to event (months) | Site of recurrence | Histology at recurrence | HER2 at recurrence | ER/PR at recurrence |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | Distant recurrence | 9 | Mastectomy | 0/2 | 0%/0% | No | No | 18.9 | Liver | Adenocarcinoma | 3+ | 0%/0% |
2 | Distant recurrence | 2 | Lumpectomy | 0/3 | 70%/0% | Letrozole until event | TH x 9 weeks | 3.8 | Leptomeningeal | Diagnosed on imaging | Unavailable | Unavailable |
3 | New primary | 11 | Mastectomy | 0/1 | 0%/0% | No | No | 145.7 | Contralateral breast | Invasive ductal carcinoma | 0 | 95%/95% |
4 | Local recurrence | 3 | Lumpectomy + RT | 0/1 | 50%/30% | Anastrozole until event | No | 34.5 | Ipsilateral breast | DCIS-MI, 2 foci | Unavailable | 70%/Unavailable |
5 | Local recurrence | 1 | Mastectomy | 0/1 | 90%/15% | Tamoxifen (≥5 y) | No | 75.9 | Ipsilateral breast | Invasive ductal carcinoma | 3+ | 90%/2% |
6 | Local recurrence | 1 | Lumpectomy + RT | None | 0%/0% | No | No | 102.0 | Ipsilateral breast | DCIS-MI, few foci | At least 2+, FISH unavailable | 0%/Unavailable |
7 | Local recurrence | 1 | Lumpectomy + RT | 0/5 | 0%/0% | No | No | 11.5 | Ipsilateral breast | DCIS-MI, single focus | Unavailable | 3%/3% |
8 | Local recurrence | 1 | Lumpectomy + RT | None | 0%/0% | No | No | 38.1 | Ipsilateral breast | DCIS-MI, single focus | 3+ | 99%/99% |
9 | Local recurrence | Unavailable | Mastectomy | 0/6 | 0%/0% | No | No | 39.3 | Ipsilateral chest wall | Invasive ductal carcinoma | 3+ | 95%/95% |
10 | Local recurrence | 5 | Lumpectomy + RT | 0/2 | 90%/10% | Anastrozole until event | No | 52.3 | Ipsilateral breast | DCIS-MI, single focus | Unavailable | Unavailable |
11 | Death due to non-breast malignancy | 3 | Mastectomy | 0/1 | 99%/0% | No | No | 6.7 | N/A | N/A | N/A | N/A |
12 | Death due to non-breast malignancy | 1 | Mastectomy | 0/3 | 90%/0% | Tamoxifen (5 y) | No | 86.9 | N/A | N/A | N/A | N/A |
13 | Death due to unknown cause | 3 | Lumpectomy + RT | None | 0%/0% | No | No | 28.3 | N/A | N/A | N/A | N/A |
