Fig. 3: OS according to TILs in HER2 + mBC patients.

The images consist of Kaplan–Meier survival curves illustrating the OS of HER2+ mBC enrolled patients according to the TILs level. The green curves represent those patients with low TILs levels, while the orange curve represents those with high TIL levels. The number of patients at risk at various time points is displayed below the survival curves for both TIL groups. a Kaplan–Meier survival curves using the 25° percentile (5%) as a cut-off for a high/low TIL score. The median OS for patients with high TIL levels is significantly longer than for those with low TIL levels, as indicated by the p-value of 0.04. b Kaplan–Meier survival curves using the 50° percentile (10%) as a cut-off for a high/low TIL score. The median difference in OS between the two groups is not statistically significant, with a p-value of 0.58. c Kaplan–Meier survival curves using the 75° percentile (15%) as a cut-off for a high/low TIL score. The median difference in OS between the two groups is not statistically significant, with a p-value of 0.38. mBC metastatic breast cancer, OS overall survival, TILs tumor-infiltrating lymphocytes.