Table 2 Correlations between TILS (continuous) and clinical pathological characteristics

	All cohort (n = 110)		Cohort TILs on metastatic site (n = 57)
Parameters	TILs median (IQR)	p-value^a	TILs median (IQR)		p-value^a
Menopausal status
Premenopausal	10 (5–15)	0.323	10 (5–15)		0.090
Postmenopausal	10 (5–20)	0.323	10 (5–20)		0.090
Stage at diagnosis
M0	10 (5–15)	0.472	10 (5–15)		0.368
M1	10 (5–20)	0.472	12.5 (5–20)		0.368
Neoadjuvant chemotherapy
No	10 (5–20)	0.306	10 (5–17.5)		0.534
Yes	10 (5–15)	0.306	10 (5–15)		0.534
ER status
Negative	10 (6.3–15)	0.083	10 (5–15)		0.788
Positive	10 (5–15)	0.083	10 (5–20)		0.788
PR status
Negative	10 (5–15)	0.279	10 (5–15)		0.836
Positive	10 (4–15)	0.279	10 (2.5–20)		0.836
HR status^b
Negative	10 (6–15)	0.080	10 (5–15)		0.788
Positive	10 (5–15)	0.080	10 (5–20)		0.788
HER2 status
2+	10 (5–15)	0.889	10 (5–17.5)		0.151
3+	10 (5–15)	0.889	10 (5–15)		0.151
Visceral disease
Yes	10 (5–15)	0.048	10 (5–11.3)		0.428
No	15 (5–20)	0.048	15 (5–15)		0.428
Brain disease
Yes	15 (10–15)	0.383	5 (3.5–10)		0.444
No	10 (5–15)	0.383	10 (5–15)		0.444
Site of TILs evaluation
Metastatic site	10 (5–15)	0.590	Liver	5 (5–10)	0.0313
			Lung	15 (10–30)
			Lymph node	12.5 (2.8–18.8)
			Soft Tissue	10 (5.0–16.3)
			Bone	7.5 (3.8–11.3)
Primary BC	10 (5–15)		//
Best response
Complete response	12.5 (8.8–15)	0.554	10 (7.5–15)		0.148
Partial response	10 (5–15)		7.5 (5–15)
Stable disease	10 (5–20)		10 (5–20)
Progression disease	10 (10–15)		2 (2–2)
Alive status
Alive	10 (5–15)	0.088	10 (5–15)		0.010
Dead	5 (5–15)	0.088	5 (2.8–10)		0.010

On the left the whole cohort and on the right the cohort of patients whose TILs were evaluated at the metastatic site.
BC breast cancer, ER estrogen receptor, HR hormone receptor, IQR interquartile range, PR progesterone receptor, TILs tumor-infiltrating lymphocytes.
^ap-values are referred to Mann–Whitney test or Kruskall–Wallis test depending on the number of clinical pathological characteristics’ categories (two or more than two, respectively).
^bHR: HR+ i.e. ER or PR positive.

Quick links

Search