Fig. 3: Repertoire of somatic genetic alterations in ER-positive/HER2-negative primary ductal and metastatic lobular breast cancer in elderly patients.

Recurrent somatic genetic alterations in primary ER+/HER2- invasive ductal carcinoma of no special type (IDC-NST; a) and in metastatic lobular breast cancer (ILC; e) in elderly (primary IDC-NST, n = 133; metastatic ILC, n = 25), middle-aged (primary IDC-NST, n = 287; metastatic ILC, n = 90), and young (primary IDC-NST, n = 139; metastatic ILC, n = 32) patients. Cases are shown in columns and genes in rows. Genetic alterations are color coded according to legend. Forest plots depicting odds ratio (OR) of cancer genes altered at statistically significantly different rates between young and elderly (b, f) and middle-aged and elderly patients (c, g). Dominant mutational signatures in primary IDC-NST (d) and metastatic ILC (h) ER+/HER2- BC in elderly, middle-age, and young patients. (i) Lollipop plot of ERBB2 mutations in metastatic ER+/HER2- ILC in elderly, middle-aged, and young patients. ERBB2 domains and mutations are color coded according to the legend. n.s., non-significant; *P < 0 .05, **P < 0.01, ***P < 0.001; Mann-Whitney U test and Fisher’s exact test. IDC-NST invasive ductal carcinoma of no special type, HRD homologous recombination deficiency, ILC invasive lobular carcinoma, mixed D-L mixed ductal-lobular.