Fig. 2: Somatic genetic alterations in invasive breast carcinomas associated with microglandular adenosis. | npj Breast Cancer

Fig. 2: Somatic genetic alterations in invasive breast carcinomas associated with microglandular adenosis.

From: Breast carcinomas associated with microglandular adenosis are linked to germline alterations in homologous recombination-deficiency genes

Fig. 2

Heatmap depicting individual cases are displayed in columns, while genes are organized in rows. Phenobars in the right panel indicate the invasive carcinoma subtype, the sample type sequenced, identified genetic alterations and IMPACT-HRD scores (A). IMPACT-HRD scores across cases (B), including number of telomeric imbalances, nTAI (C), large scale state transitions, LST(D) and genome wide loss of heterozygosity, LOH (E). TMB tumor mutational burden, FGA fraction of genome altered, HRD homologous recombination deficiency, WGD whole genome duplication, IBC-MGA invasive breast carcinoma associated with microglandular adenosis, LOH loss of heterozygosity, P/LPV pathogenic/likely pathogenic variant, VUS variant of unknown significance.

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