Fig. 2: Comparison of PIK3CA VAFs between SSS and AVENIO assays. | npj Breast Cancer

Fig. 2: Comparison of PIK3CA VAFs between SSS and AVENIO assays.

From: Clinical impact of single-gene vs. panel sequencing in advanced HR + /HER2− breast cancer: insights and implications

Fig. 2

A Bland-Altman plot showing the agreement between PIK3CA VAFs. B Linear regression analysis with a mixed-effects model demonstrates a strong correlation between the two methods (coefficient: 0.94, 95% CI: 0.89–0.99; p < 0.001). C Classification of PIK3CAwt liquid biopsy samples detected by SSS and AVENIO. Bar plots show the proportion of PIK3CAwt samples classified as true negative (green) and non-informative (grey) using different criteria. hVAF# includes only pathogenic or likely pathogenic variants, and hVAF* additionally includes VUS.

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