Fig. 3: microRNAs Inhibit BSG-mediated Breast Cancer Metastasis.
From: The pleiotropic roles of non-hormonal receptor basigin and regulatory microRNAs in breast cancer
When uninhibited (a), the transcription and translation of BSG facilitates remodeling of the ECM via enhanced lactate efflux caused by MCTs, CD44-mediated hyaluronan synthesis, and MMP-modulated TME, enabling EMT and metastasis. Interruption of BSG transcription (b) by miR-22 (green color) – via competitive binding to transcriptional promoter Sp1 or translational inhibition (c) when miR-22 or miR-890 (red color) – bind to BSG mRNA interrupt BSG-mediated BC progression. Both miRs have been identified as onco-suppressors and are downregulated in breast cancer. Created in BioRender. Richard, V. (2025) https://BioRender.com/3pvuezw and https://BioRender.com/n95jnw5.
