Table 1 Summary table of the results found in the systematic literature analysis
From: MiRNA expression as outcome predictor in pediatric AML: systematic evaluation of a new model
miRNA/miRNA signature | Article | Pediatric AML patients | Data origin | Association with hazard (OS) | Log rank test p-value (OS) | Association with hazard (EFS) | Log rank test p-value (EFS) | Multivariate Cox regression analysis | Multivariate Cox p-value (OS) | Multivariate Cox p-value (EFS) |
|---|---|---|---|---|---|---|---|---|---|---|
miR4 signature (4 miRNAs) | R. Zhu et al. 28 | n = 229 (miRNA-seq) | TARGET project, USA. | Positive | No | Positive | 0.033 | Yes | <0.001 | No |
miR3 signature (3 miRNAs) | R. Zhu et al. 29 | n = 59 (CN-AML) (miRNA-seq) | Positive | <0.001 | Positive | <0.001 | Yes | 0.003 | <0.001 | |
AMLmiR36 signature (36 miRNAs) | Lim et al. 30 | n = 1362 (miRNA-seq) | AAML0531, AAML03P1, CCG-2961 and AAML1031 (data later became TARGET), USA. | No | No | Positive | <0.001 | Yes | No | <0.001 |
miR24 signature (24 miRNAs) | Esperanza-Cebollada et al. 26 | n = 39 (RT-qPCR) + n = 447 (miRNA-seq) | Hospital Sant Joan de Déu (HSJD), Spain, and TARGET project, USA, respectively. | Positive | 0.024 | Positive | 0.003 | Yes | 0.043 | 0.008 |
miR-199a | Qi and Zhang15 | n = 71 (APL excluded) (RT-qPCR) | Guizhou Provincial People’s Hospital, China. | Negative | – | Negative | 0.021 | No | No | No |
miR-381 | Zhang et al. 31 | n = 102 (RT-qPCR) | Linyi People Hospital, China. | Negative | 0.011 | Negative | 0.004 | Yes | 0.011 | No |
miR-206 | Liu et al. 16 | n = 73 (RT-qPCR) | Daqing Longnan Hospital, China. | Negative | 0.028 | Negative | 0.041 | No | No | No |
miR-193b-3p | Bhayadia et al. 32 | n = 161 (RT-qPCR) | Dutch Childhood Oncology Group (DCOG); AML ‘Berlin-Frankfurt-Münster’ Study Group (AML-BFM-SG); Czech Pediatric Hematology Group (CPH); St. Louis Hospital in Paris. | Negative | 0.002 | Negative | 0.018 | Yes | 0.018 | 0.016 |
miR-139-5p | Emmrich et al. 17 | n = 165 (RT-qPCR) | Negative | 0.001 | Negative | – | No | No | No | |
miR-100 | Kuai et al. 33 | n = 106 (RT-qPCR) | Huai’an First People’s Hospital, China. | Positive | 0.006 | Positive | 0.008 | Yes | 0.01 | 0.03 |
miR-195 | Hong et al. 34 | Negative | 0.001 | Negative | 0.001 | Yes | 0.02 | 0.02 | ||
miR-375 | Wang et al. 35 | Positive | 0.001 | Positive | 0.001 | Yes | 0.01 | 0.01 | ||
miR-335 | Lin et al. 36 | Positive | 0.001 | Positive | 0.001 | Yes | 0.01 | 0.01 | ||
miR-370 | Lin et al. 37 | Negative | 0.001 | Negative | 0.001 | Yes | 0.01 | 0.01 | ||
miR-29a | C. Zhu et al. 38 | Negative | 0.008 | Negative | 0.001 | Yes | 0.005 | 0.001 | ||
miR-34b | Qi et al. 44 | n = 72 (RT-qPCR) | Negative | 0.001 | No | No | No | No | No | |
miR-122 | Yang et al. 39 | n = 116 (RT-qPCR) | Huai’an Hospital Affiliated to Xuzhou Medical College, Huai’an First People’s Hospital and Huai’an Second People’s Hospital. China. | Negative | 0.001 | Negative | 0.001 | Yes | 0.006 | 0.02 |
miR-192 | Tian et al. 40 | n = 97 (RT-qPCR) | Affiliated Hospital of Binzhou Medical University, China. | Negative | 0.024 | Negative | 0.013 | Yes | 0.011 | 0.008 |
miR-155 | Narayan et al. 14 | n = 60 (RT-qPCR) | Royal Children’s Hospital and the Children’s Hospital at Westmead, Australia. | Positive | – | Positive | – | No | No | No |
Ramamurthy et al. 41 | n = 198 (RT-qPCR) | Children’s Oncology Group (AAML0531), USA. | Positive | 0.002 | Positive | 0.001 | Yes | 0.022 | 0.019 | |
L. H. Xu et al. 42 | n = 83 (RT-qPCR) | Children’s Hospital of Soochow University, China. | Positive | 0.011 | No | No | No | No | No | |
miR-196b | L. Xu et al. 43 | Positive | <0.001 | No | No | No | No | No |
