Fig. 1: Segregating germline variants in familial meningiomas.
From: Novel germline and somatic variants in familial and sporadic meningioma genes
Pedigrees of four families with meningiomas and variants segregating in each family. Family A: Four affected members of a German family with spinal and cranial meningiomas were hererozygous for missense variant p.Pro9Leu (rs762408148) in RARA. Family B: Two heterezygous missenses variants p.Lys419Glu and p.Ser75Phe in BMPR1A and FNDC3B, respectively, segregated in three affected members of a French family. Family C: In a family with Ashkenazi jewish origin, three affected members with multiple meningiomas and one unaffected member with breast cancer were heterozygous for the missense variant p.Arg3849Gln (rs375687974) in FAT3. Family D: Two heterozygous variants, p.Asp11Asn and p.Arg660Gln in TNRC6A and EXTL3, segregated in one affected member in a Moroccan family.
