Fig. 3: Linkage Disequilibrium Score Regression genetic correlations and hierarchical clustering for atrial fibrillation, coronary artery disease and heart failure.
On the left, barplots depicting genetically correlated traits with atrial fibrillation and flutter [AF], coronary artery disease [CAD], and heart failure [HF] at a significance level PFDR ≤ 0.05. rg and 95% confidence intervals are represented; all rg values appear in Supplementary Data 4–6. On the right, hierarchical clustering of the traits with rg > 0.20 and PFDR ≤ 0.01 with AF, CAD and HF. The Euclidean distance and the complete method were used to obtain three clusters grouping the traits significantly correlated with AF, CAD, and HF. For each of the 3 clusters, the trait with the highest genetic correlation with the trait of interest was selected for multi-trait analysis of GWAS (marked with an asterisk). PFDR, P-value corrected by false discovery rate; rg, genetic correlation. Other abbreviations as per Supplementary Data 1.
