Fig. 4: Miami plots of single-trait and multi-trait summary statistics.

Miami plots from the summary statistics of the original studies and from the MTAG results. Panels (A, B, and C) depict Miami plots for atrial fibrillation and flutter [AF], coronary artery disease [CAD], and heart failure [HF], respectively. The plots of Nielsen et al. for AF, Nelson et al. for CAD and Shah et al. for HF, are depicted at the top, and from the disease-specific MTAG results at the bottom. In AF, MTAG increased the number of identified significant loci from 119 to 138, in CAD from 50 to 135, and in HF from 11 to 61. This led to the identification of 19 novel loci not reported in the original summary statistics for AF, 89 for CAD and 52 for HF. Red dashed line shows the genome-wide significance threshold (P = 5 × 10⁻⁸).