Fig. 5: The potential molecular task-force of GM-derived metabolites for PINE network modulation.
From: Spaceflight exposome/microgravity effects on the psychoimmunoneuroendocrine system
The most important gut-derived metabolites are depicted with potential effect on molecular signaling for PINE network. The potential host receptors, which could be modulated, are highlighted in red. D-AAs Amino Acid with D configuration, NAEs N-acylethanolamines, 2-MAGs 2-monoacylglycerols, GABA, γ-aminobutyric acid, BCFAs Branched chain fatty acid, SCFAs short chain fatty acids, AhR aryl hydrocarbon receptor, NMDA N-methyl D-aspartate receptor, DRs Dopamine receptors, PPARs peroxisome proliferator-activated receptors, CB1 cannabinoid receptors type 1, 5-HTRs serotonine receptors, GCPRs/FFARs G-coupled Protein Receptors/Free Fatty Acid Receptors, CB2 cannabinoid receptors type 2, TLRs toll-like receptors.
