Table 1 Effects of spaceflight exposome/microgravity in lipid signaling of immune cells and cell lines
From: Spaceflight exposome/microgravity effects on the psychoimmunoneuroendocrine system
References | Experimental set up | Sample | Target | Effect |
|---|---|---|---|---|
Maccarrone et al. 122 | RPM | K562 cells | COX-2 | Enhanced activity |
Maccarrone et al. 123 | Parabolic flight | Purified enzyme | 15-LOX-1 | Enhanced activity |
Maccarrone et al. 124 | RPM | Lymphocytes, U937 cells | 5-LOX | Enhanced activity |
Choukèr et al. 125; Strewe et al. 126 | Parabolic flight | Human blood | AEA | Enhanced production |
Gasperi et al. 127 | RCCS | Jurkat T cells | 5-LOX | Enhanced activity |
Battista et al. 128 | ISS | PBMCs | 5-LOX | Enhanced activity |
AEA | Enhanced production | |||
NAPE-PLD | Up-regulation (both mRNA and protein) | |||
FAAH | Down-regulation (both mRNA and protein) | |||
Buchheim et al. 54 | ISS | Human Blood | AEA | Enhanced production |
Kim et al. 25 Leuti et al. 46 | RCCS | Primary Human Monocytes | RvD1 | Reduced biosynthesis |
