Fig. 5: Hybrid encapsulation strategies for long-term mechanical and interfacial stability in flexible biosensors.
From: Mechanics and bio-interface engineering in flexible biosensors for continuous health monitoring
a The cross-section of a typical parylene-PDMS encapsulated sensor via SEM (left) and representative electrical signal stability under cyclic mechanical loading enabled by strain-isolated barrier layers (right)99. b Schematic preparation steps of a fluorinated elastomer network (left), with representative sensor output signals demonstrating mechanical robustness and environmental stability (right)100. c Schematic of mechanically interlocked hydrogel–elastomer hybrid structure, alongside on-skin application images demonstrating conformal contact and deformation-tolerant operation (right)169. d Preparation of zwitterionic hydrogel coatings through sequential initiator diffusion and UV-triggered polymerization (top) combined with a conceptual illustration of protein-resistant, hydrated interfaces enabling stable long-term signal acquisition at the interface (bottom)102.
