Fig. 9: The schematic diagram illustrates the augmenting implications of circadian disruption on O-αSyn-induced neurodegeneration.
From: Circadian disruption promotes the neurotoxicity of oligomeric alpha-synuclein in mice
O-αSyn can induce the burden of nitrated-αSyn pathology in the brain. Both O-αSyn and nitrated αSyn exhibit high toxicity to neurons, with the effects of nitrated αSyn demonstrating greater persistence. Circadian disruption enhances the production of nitrated αSyn by exacerbating neuroinflammation and nitrative stress, which accelerates neurodegenerative progression.
