Fig. 2: Radiological heterogeneity and α-syn SAA positivity in patients with LBD. | npj Parkinson's Disease

Fig. 2: Radiological heterogeneity and α-syn SAA positivity in patients with LBD.

From: α-synuclein seed amplification assay sensitivity may be associated with cardiac MIBG abnormality among patients with Lewy body disease

Fig. 2

A–C Striatal DAT Z-SBR and cardiac MIBG delayed H/M ratio of each patient. Vertical and horizontal dot lines represent predetermined cut-off lines. A Although normal cardiac MIBG was observed in 41% (14/34) of patients with PD, all patients with DLB showed decreased cardiac MIBG H/M ratio irrespective of DAT measure. B Plots are limited to patients with PD. Not only those meeting the probable PD criteria but also 15% of those meeting clinically established MDS-PD criteria showed normal cardiac MIBG results. C Plots of all patients with LBD and their α-syn SAA positivity. D The difference in α-syn SAA positivity between MIBG normal and abnormal groups was significant for both analyses limited to patients with PD (85.0% vs 14.3%, p < 0.001) and patients with clinically established PD (91.7% vs 0%, p < 0.01).

Back to article page