Fig. 1: Pedigrees of identified families in this study.

Pedigree of Family GP2-FAM-1 (A), CANADA-FAM-1 (B), and AMP-FAM-1 (C) with the LRRK2 p.L1795F variant. The pedigrees were drawn based on reported family history and may be incomplete. The index cases are indicated with arrows. Affected individuals are indicated by black symbols: circles (female) and squares (male). Diamond is where sex is undefined. Unaffected individuals are indicated by open symbols. Unaffected variant carriers are indicated by open symbols with a dot in the middle. A diagonal line indicates deceased individuals. Red circle indicates individuals with genetic data available (WGS data for GP2-FAM-1 and AMP-FAM-1, single gene testing for CANADA-FAM-1). Heterozygous mutant (m) and wild-type (wt) genotypes are indicated with corresponding age at the sample collection (age) and age at motor symptom onset (if known; AAO). A The mother of GP2-FAM-1 index was reported to have eight additional siblings (#), several of whom are clinically affected with PD; however, no detailed family history is available for these relatives. B One maternal aunt (II-1) of the CANADA-FAM-1 index was reported to have had Alzheimer’s disease (##).