Fig. 2: Variant-level associations and PoPS results for selected loci.
From: Prioritizing Parkinson’s disease risk genes in genome-wide association loci
The upper portion of each sub-plot is a LocusZoom plot. Each point represents a different genetic variant, the x-axis represents physical position on the listed chromosome, the left y-axis represents –log10-transformed P value, the right y-axis represents the recombination rate, color represents linkage disequilibrium with the lead variant in the locus (as shown in the legend), and the horizontal dashed line represents the genome-wide significance P value threshold of 5 × 10–8. The lower portion of each figure is a PoPS plot. Genes are denoted as blue bars spanning from their transcription start site to their transcription stop site using the same x-axis as the LocusZoom plot, the y-axis represents the raw PoPS score, the dashed horizontal gray lines represent the top 10% and 1% of PoPS scores genome-wide, and the solid horizontal gray line represents a PoPS score of 0.
