Table 2 Diagnostic accuracy of CSF NfL discriminating PD and PD-CI from APD

From: Head-to-head comparison of four cerebrospinal fluid and three plasma neurofilament light chain assays in Parkinsonism

 

AUC (95% CI)

NfL assay

CSF NfLELISA

CSF NfLCLEIA

CSF NfLSIMOA

CSF NfLELLA

Entire cohort

    

PD vs APD

0.973 (0.960–0.985)

0.974 (0.962–0.986)

0.966 (0.951–0.982)

0.969 (0.955-0.983)

PD-CI vs APD

0.904 (0.863–0.945)

0.924 (0.891–0.956)

0.898 (0.858–0.937)

0.918 (0.885–0.952)

Subcohorts

    

PD vs MSA

0.994 (0.987–1.00)

0.991 (0.982–1.00)

0.989 (0.976–1.00)

0.990 (0.980–1.00)

PD-CI vs MSA

0.967 (0.940–0.993)

0.976 (0.956–0.995)

0.956 (0.928–0.985)

0.973 (0.952–0.994)

PD vs PSP/CBS

0.949 (0.925–0.973)

0.954 (0.932–0.976)

0.941 (0.913–0.969)

0.946 (0.920–0.971)

PD-CI vs PSP/CBS

0.833 (0.769–0.898)

0.865 (0.808–0.921)

0.831 (0.768–0.894)

0.857 (0.800–0.914)

  1. APD atypical parkinsonian disorder, MSA multiple system atrophy, PD Parkinson’s disease, PD-CI PD-cognitively impaired, PSP/CBS progressive supranuclear palsy/corticobasal syndrome.
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