Table 3 Diagnostic accuracy of plasma NfL discriminating PD and PD-CI from APD

From: Head-to-head comparison of four cerebrospinal fluid and three plasma neurofilament light chain assays in Parkinsonism

 

AUC (95% CI)

  

NfL assay

Plasma NfLCLEIA

Plasma NfLSIMOA

Plasma NfLELLA

Entire cohort

   

PD vs APD

0.917 (0.891–0.943)

0.924 (0.898–0.949)

0.918 (0.892–0.945)

PD-CI vs APD

0.771 (0.696–0.846)

0.783 (0.708–0.858)

0.788 (0.715–0.861)

Subcohorts

   

PD vs MSA

0.926 (0.898–0.955)

0.936 (0.909–0.963)

0.940 (0.914–0.966)

PD-CI vs MSA

0.783 (0.705–0.862)

0.809 (0.732–0.886)

0.821 (0.746–0.897)

PD vs PSP/CBS

0.907 (0.873–0.941)

0.910 (0.876–0.943)

0.896 (0.859–0.932)

PD-CI vs PSP/CBS

0.758 (0.675–0.841)

0.753 (0.668–0.839)

0.752 (0.669–0.835)

  1. APD atypical parkinsonian disorder, MSA multiple system atrophy, PD Parkinson’s disease, PD-CI PD-cognitively impaired, PSP/CBS progressive supranuclear palsy/corticobasal syndrome.
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