Fig. 11: Molecules involved in insulin signaling are altered in the olfactory bulb of α-Syn-HFD mice. | npj Parkinson's Disease

Fig. 11: Molecules involved in insulin signaling are altered in the olfactory bulb of α-Syn-HFD mice.

From: Metabolic dysregulation and resistance to high-fat diet-induced weight gain in mice overexpressing human wild-type α-synuclein

Fig. 11

Western blot analysis of regulators of insulin signaling and synaptic plasticity in the olfactory bulb of the 4-month male group. Statistical analysis was performed using unpaired t-tests, comparing α-Syn and control mice separately for each diet group. P = 0.0095 (IGF-IRβ), P = 0.0008 (p IGF-IRβ), P = 0.0359 (p IR), P = 0.0001 (p Akt), P = 0.0053 (p GSK), P = 0.0006 (p mTOR), P = 0.0293 (PSD-95), P = 0.0340 (synaptophysin), and P = 0.0001 (human α-synuclein).

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